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折扣/货期| 货号：33-574 | 规格：100 ug | 目录价：￥10986.3 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
E-Cadherin Antibody [CDH1/1525]
别名:
Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO
反应种属:
Human
宿主来源:
Mouse
实验应用:
Flow,IF,WB,IHC-P
靶标/特异性:
Not suitable for Mouse, Rat sample testing
同种型:
IgG1, kappa
克隆性:
Monoclonal
克隆号:
CDH1/1525
纯化方式:
Protein G affinity chromatography
偶联:
Unconjugated
产品浓度:
0.2 mg/mL
保存温度:
Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
产地:
美国
生产商:
Prosci
功能与背景:
Recognizes a protein of 80-120kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
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