HLA-DRB1 Antibody (MHC II)-单抗-深圳欣博盛生物科技有限公司

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HLA-DRB1 Antibody (MHC II)

品牌：NSJ Bio

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说明书

折扣/货期

货号：V2591-100UG	规格：100 ug	目录价：￥6652.1
货号：V2591-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

HLA-DRB1 Antibody (MHC II)

产品描述:

This mAb reacts with the HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR, which depends on the correct folding of the alpha/beta heterodimer. This mAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

反应种属:

Human

宿主来源:

Mouse

实验应用:

FACS, IF

同种型:

Mouse IgG2a, kappa

免疫原:

Activated human peripheral blood mononuclear cells were used as the immunogen for the HLA-DRB1 antibody.

克隆性:

Monoclonal (mouse origin)