官网链接
折扣/货期| 货号：3655-0.02 mg | 规格：0.02 mg | 目录价：￥1345.5 |
| 货号：3655-0.1 mg | 规格：0.1 mg | 目录价：￥6084 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IRE1p Antibody
别名:
IRE1p Antibody: IRE1, IRE1P, IRE1a, hIRE1p, IRE1, Endoplasmic reticulum-to-nucleus signaling 1
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
ELISA,WB,ICC,IF,IHC-P
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
IRE1p Antibody is affinity chromatography purified via peptide column.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
IRE1p antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
IRE1p Antibody is supplied in PBS containing 0.02% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Accession #:
O75460
您可能感兴趣的产品
Growth Hormone (rat) Polyclonal Antibody for IHC
货号：C03904.25 µl
Goat Anti-ImmunoglobulinG (mouse) Polyclonal Antibody
货号：C03757.10 ml
Goat Anti-ImmunoglobulinG (rat) Polyclonal Antibody
货号：C03756.10 ml
Goat Anti-ImmunoglobulinG (guinea pig) Polyclonal Antibody
货号：C03755.10 ml
Sheep Anti-ImmunoglobulinG (guinea pig) Polyclonal Antibody
货号：C03754.10 ml
Horse Anti-ImmunoglobulinG (rabbit) Polyclonal Antibody
货号：C03753.5 ml
CRF (ovine) Polyclonal Antibody
货号：C03171.500 dtn
Methionine Enkephalin Polyclonal Antibody
货号：C03170.500 dtn
复制QQ号成功，请打开QQ后添加好友进行咨询