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折扣/货期| 货号：80-048 | 规格：0.1 mg | 目录价：￥6598.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NF- kappaB p65 (phospho Ser281) Antibody
别名:
NFKB3, Nuclear factor NF-kappa-B p65 subunit, RELA, TF65, p65
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
The antibody detects endogenous level of NF- kappaB p65 only when phosphorylated at serine 281.
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
Store antibody at -20˚C for up to one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产地:
美国
生产商:
Prosci
功能与背景:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.
Accession #:
NP_001138610.1
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