Niemann Pick C1 Antibody / NPC1-多抗-深圳欣博盛生物科技有限公司

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Niemann Pick C1 Antibody / NPC1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ7282

规格：100 ug

目录价：￥6488.05

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Niemann Pick C1 Antibody / NPC1

产品描述:

Niemann-Pick disease, type C1 (NPC1) is a membrane protein that mediates intracellular cholesterol trafficking in mammals. In humans it is encoded by the NPC1 gene (chromosome location 18q11). This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-absorbance lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, FACS

同种型:

Rabbit IgG

免疫原:

Amino acids YHTVLQTSADFIDALKKARLI were used as the immunogen for the Niemann Pick C1 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity purified

保存温度:

After reconstitution, the Niemann Pick C1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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