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anti-IDO1 (human), mAb (ID 177)
品牌： Adipogen
产品货号： AG-20A-0035-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-IDO1 (human), mAb (ID 177)
  • 别名:
    Indoleamine 2,3-dioxygenase 1; IDO; INDO
  • 产品描述:
    IDO1 is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO1 protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system’s ability to destroy pathogens. By reducing the number of effector T cells, IDO1 overexpression prevents the immune system from effectively destroying cancer cells. IDO1 overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung cancer. Physiological IDO1 activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    ELISA, IHC, WB
  • 靶标/特异性:
  • 同种型:
    Mouse IgG1kappa
  • 推荐稀释度:
  • 免疫原:
    Recombinant human IDO1.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    ID 177
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
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  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
  • 产品特点:
  • 纯度:
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  • 分子式:
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  • PubChem CID:
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