anti-Asprosin (human), mAb (Birdy-2) - 深圳欣博盛生物科技有限公司

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anti-Asprosin (human), mAb (Birdy-2)

品牌： Adipogen

产品货号： AG-20B-0074-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-Asprosin (human), mAb (Birdy-2)
别名:

Fibrillin-1 C-terminal Cleavage Product; FBN1 C Terminal Cleavage Product
产品描述:

Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein Kinase A. Reduction of Asprosin levels protects against metabolic syndrome-associated hyperinsulinism. Asprosin may act as a circulating hunger signal. Indeed, peripherally injected recombinant asprosin can cross the blood-brain barrier and intracerebroventricular (i.c.v.) injection of recombinant asprosin stimulated appetite in wild-type mice, indicating a central mechanism of action. Loss of Asprosin in mice and human leads to decreased fat mass and body weight, and hypophagia. Mice are also completely protected from the development of diet-induced obesity. Asprosin works by stimulating the orexigenic AgRP+ (Agouti related neuropeptide) neurons via a cAMP-dependent pathway and by inhibiting the anorexigenic neurons POMC+ (pro-opiomelanocortin) neurons in a GABA-dependent manner. Mutation in Asprosin in human leads to the pattern of metabolic dysregulation, including partial lipodystrophy, accompanied by reduced plasma insulin. Due to its key role in food regulation, Asprosin function could serve as a potentially unique therapeutic target against obesity, diabetes or metabolic diseases.
反应种属:
宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.
实验应用:

ELISA, WB
靶标/特异性:
同种型:

Mouse IgG2a
推荐稀释度:
免疫原:

Recombinant human asprosin.
免疫原种属:
克隆性:
克隆号:

Birdy-2
纯化方式:
偶联:
产品浓度:

1mg/ml
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
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检测方法:
样本类型:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
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PubChem CID: