anti-APRIL (human), mAb (blocking) (Mahya-1) (preservative free)

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品牌： Adipogen

产品货号： AG-20B-0078PF-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-APRIL (human), mAb (blocking) (Mahya-1) (preservative free)
别名:

A Proliferation Inducing Ligand; TNFSF13; CD256; TALL-2
产品描述:

The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. APRIL binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA), and heparan sulfate proteoglycans (HSPG) within the extracellular matrix or on the surface of cells such as plasma cells. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). APRIL is expressed by a number of myeloid-derived cell types including BM granulocytes, megakaryocytes, eosinophils and osteoclasts and by dendritic cells following exposure to IFN-alpha, IFN-gamma or CD40L. APRIL expression is induced during hematopoiesis in the bone marrow. APRIL expression is not limited to cells of myeloid origin, but can also be found in epithelial cells of the gut, tonsil, breast and skin. Finally, APRIL is expressed in tumor cell lines and human cancer cells of colon, thyroid and lymphoid origin. APRIL (a proliferation-inducing ligand) is implicated in several human autoimmune diseases with autoreactive B cell involvement, including systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), IgA nephropathy (IgAN) and rheumatoid arthritis (RA). APRIL might also function in enhancing proliferation of some tumor cells, especially B cell malignancies.
反应种属:
宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.
实验应用:

ELISA, FUNC (Blocking), IP
靶标/特异性:
同种型:

Mouse IgG1kappa
推荐稀释度:
免疫原:

Recombinant human APRIL (aa 98-233).
免疫原种属:
克隆性:
克隆号:

Mahya-1
纯化方式:
偶联:

Preservative Free
产品浓度:

1mg/ml
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS.
有效期:

Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. In PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:

<0.01EU/µg purified protein (LAL-test; Lonza)
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: