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anti-Lewis y/b hapten (human), mAb (SC104) (preservative free)
品牌： Adipogen
产品货号： AG-20B-6002PF-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-Lewis y/b hapten (human), mAb (SC104) (preservative free)
  • 别名:
    CD174; Sialyltetraosylceramide; NCRC37
  • 产品描述:
    Membrane glycolipids represent an unexplored source of tumor-associated antigens. Many of these are overexpressed and altered in tumors compared to normal tissue. Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, has provided a novel area of targets for cancer immunotherapy. Lewis-y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be overexpressed on breast, lung, colon and ovarian cancer cells. Clone SC104 recognizes a unique cell surface antigen sialyltetraosylceramide, expressed by 90% of colorectal tumors at all clinical stages. SC104 targets colorectal cancer-associated glycolipids and induces tumor cell death in vitro independently of CDC or ADCC or blockade of known survival signaling pathways. It induces apoptotic cell death and synergizes with chemotherapy in vivo in mice.
  • 反应种属:
  • 宿主来源:
    Purified from concentrated hybridoma tissue culture supernatant.
  • 实验应用:
    ELISA, FACS, FUNC (Blocking), ICC, IHC
  • 靶标/特异性:
  • 同种型:
    Mouse IgG1
  • 推荐稀释度:
  • 免疫原:
    Tissue cultured colorectal tumor cell lines (C170, C146, Colo205 and JW).
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    SC104
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    Lot dependent
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <0.001EU/µg purified protein (LAL test; Lonza).
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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