anti-PD-L1 (human), mAb (AG-IHC411) - 深圳欣博盛生物科技有限公司

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anti-PD-L1 (human), mAb (AG-IHC411)

品牌： Adipogen

产品货号： AG-20B-6022-R100

规格： 100 ul

报价：

折后价：

数量： - +

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产品名称:

anti-PD-L1 (human), mAb (AG-IHC411)
别名:

PD-L1; Programmed Death Ligand 1; PDCD1 Ligand 1; CD274; B7-H1; B7 Homolog 1
产品描述:

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. PD-L1 is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. PD-L1 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer and sentinel lymph node melanoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).
反应种属:
宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.
实验应用:

ELISA, IHC
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

Recombinant human PD-L1.
免疫原种属:
克隆性:
克隆号:

AG-IHC411
纯化方式:
偶联:
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保存温度:

+4°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In Tris Buffer, pH 7.4, containing 1% BSA and <0.1% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at +4°C.
产地:

瑞士
外观:
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URL:
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样本类型:

Liquid. In Tris Buffer, pH 7.4, containing 1% BSA and <0.1% sodium azide.
产品特点:
纯度:

Protein A/G purified.
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