anti-Poly(ADP-ribose) [PAR], mAb (10H) - 深圳欣博盛生物科技有限公司

您现在的位置：首页 > 产品目录 > 产品分类 > 抗体 > 一抗 > 单抗

anti-Poly(ADP-ribose) [PAR], mAb (10H)

品牌： Adipogen

产品货号： AG-20T-0001-M001

规格： 1 mg

报价：

折后价：

数量： - +

问题咨询

官网链接

说明书

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Poly(ADP-ribose) [PAR], mAb (10H)
别名:
产品描述:

Processes such as transcription, repair and replication that require efficient DNA recognition are dependent on modulation of chromatin structure. Chromatin relaxation is a critical event that occurs during DNA repair and is associated with the negatively charged polymer of adenosine 5'-diphosphate (ADP)-ribose (PAR). PAR is synthesized from nicotinamide adenine dinucleotide (NAD+) by the poly(ADP-ribose) polymerase protein family (PARPs), of which PARP-1 (and to a lesser extent PARP-2) respond to DNA-strand breaks. PARP-1 is selectively activated by DNA strand breaks to catalyze the addition of long branched chains of PAR to a variety of nuclear proteins, most notably PARP itself. The amount of PAR formed in living cells with DNA damage is commensurate with the extent of the damage. Under DNA damage conditions, PAR undergoes a rapid turnover, with a half-life in the range of minutes, as PAR is rapidly hydrolyzed and converted to free ADP-ribose by the enzyme poly(ADP-ribose)glycohydrolase (PARG). PAR regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These include transcriptional regulation, cell division, intracellular trafficking, inflammation and energy metabolism.
反应种属:
宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.
实验应用:

FACS, ICC, IHC, WB
靶标/特异性:
同种型:

Mouse IgG3kappa
推荐稀释度:
免疫原:

Purified poly(ADP-ribose).
免疫原种属:
克隆性:
克隆号:

10H
纯化方式:
偶联:
产品浓度:

1 mg/ml
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. Containing 50mM HEPES, pH 7.4, 100mM NaCl, 1% BSA and 0.02% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -80°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. Containing 50mM HEPES, pH 7.4, 100mM NaCl, 1% BSA and 0.02% sodium azide.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: