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anti-Survival Motor Neuron Protein, mAb (7B10)
品牌： Adipogen
产品货号： AG-20T-0003-C200
规格： 200 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-Survival Motor Neuron Protein, mAb (7B10)
  • 别名:
    SMN; Gemin-1; Component of Gems 1; BCD541
  • 产品描述:
    The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. It is expressed in a wide variety of tissues, including high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle and low levels in fibroblasts and lymphocytes. Mutations in SMN cause spinal muscular atrophy 1 (SMA1). Spinal muscular atrophy is a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. The antibody was used extensively to purify and characterize the macromolecular SMN complex from cultured human cells. The antibody binds with high affinity and specificity to its epitope, which comprises a sequence of up to 9 amino acids in the N-terminal part of human SMN. It allows the native elution of bound antigen with an excess of the cognate peptide. Via addition of the 7B10 epitope (TagIt epitope) to other proteins this purification strategy can also be exploited for purification of these fusion proteins and RNA-protein complexes from cells lacking this epitope on endogenous proteins, such as cells derived from C. elegans and Drosophila.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    IP, WB
  • 靶标/特异性:
  • 同种型:
    Mouse IgG1
  • 推荐稀释度:
  • 免疫原:
    Recombinant human full-length survival motor neuron protein (SMN).
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    7B10
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    2mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS and 0.02% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS and 0.02% sodium azide.
  • 产品特点:
  • 纯度:
    Protein A/G purified.
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
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  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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