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anti-PARP-10 [ARTD10] (human), mAb (5H11)
品牌： Adipogen
产品货号： AG-20T-0004-L001
规格： 1 ml

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-PARP-10 [ARTD10] (human), mAb (5H11)
  • 别名:
    ADP-ribosyltransferase Diphtheria Toxin-like 10; Poly(ADP-ribose) Polymerase-10
  • 产品描述:
    PARP-10 [ARTD10] is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta [IL-1beta] and tumor necrosis factor-alpha [TNF-alpha]. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    ICC, IP, WB
  • 靶标/特异性:
  • 同种型:
    Rat IgG1
  • 推荐稀释度:
  • 免疫原:
    Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    5H11
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at +4°C.
  • 产地:
    瑞士
  • 外观:
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  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide.
  • 产品特点:
  • 纯度:
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  • 分子式:
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  • PubChem CID:
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