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anti-TIE-2 (human), mAb (tek9)
品牌： Adipogen
产品货号： AG-20T-0103-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-TIE-2 (human), mAb (tek9)
  • 别名:
    Tyrosine Kinase with Ig and EGF Homology Domains-2; Angiopoietin-1 Receptor
  • 产品描述:
    TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1 and ultimately to the stimulation of sprouting angiogenesis.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    ELISA, FACS, WB
  • 靶标/特异性:
  • 同种型:
    Mouse IgG1
  • 推荐稀释度:
  • 免疫原:
    Recombinant human soluble extracellular domain of TIE-2.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    tek9
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Lyophilized.
  • 产品特点:
  • 纯度:
    Protein G purified.
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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