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anti-Caspase-8 (mouse), mAb (1G12)
品牌： Adipogen
产品货号： AG-20T-0137-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-Caspase-8 (mouse), mAb (1G12)
  • 别名:
    Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease
  • 产品描述:
    Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    ELISA, FACS, IHC, WB
  • 靶标/特异性:
  • 同种型:
    Rat IgG1kappa
  • 推荐稀释度:
  • 免疫原:
    Recombinant mouse caspase-8 (p20 subunit).
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    1G12
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 0.02% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS containing 0.02% sodium azide.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <0.1EU/µg purified protein (LAL test; Lonza).
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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