-
产品名称:
anti-TLR2, mAb (ABM3A87)
-
别名:
Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4
-
产品描述:
TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.
-
反应种属:
-
宿主来源:
-
实验应用:
FACS, IHC, WB
-
靶标/特异性:
-
同种型:
Mouse IgG1kappa
-
推荐稀释度:
-
免疫原:
Recombinant human TLR2 protein (aa 180-420).
-
免疫原种属:
-
克隆性:
-
克隆号:
ABM3A87
-
纯化方式:
-
偶联:
-
产品浓度:
0.5mg/ml
-
表达系统:
-
阳性对照:
-
保存温度:
-20°C
-
运输温度:
BLUE ICE
-
细胞定位:
-
预期分子量:
-
产品形式:
liquid
-
存储溶液:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
-
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.
-
产地:
瑞士
-
外观:
-
生产商:
-
功能与背景:
-
URL:
-
灵敏度:
-
检测范围:
-
检测方法:
-
样本类型:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
-
产品特点:
-
纯度:
Protein G purified.
-
生物活性:
-
内毒素水平:
-
来源:
-
表达方式:
-
Accession #:
-
CAS号:
-
分子式:
-
溶解度:
-
PubChem CID: