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anti-TLR3 (mouse), mAb (ABM24E5)
品牌： Adipogen
产品货号： AG-20T-0302-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-TLR3 (mouse), mAb (ABM24E5)
  • 别名:
    Toll-like Receptor 3; CD283
  • 产品描述:
    TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. mTLR3 shows high homology to hTLR3 in their predicted cDNA and protein sequences. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). The high levels of mTLR3 expression in marginal zone B cells perhaps contribute to their ability to clear antigen from the blood. It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
    FACS, WB
  • 靶标/特异性:
  • 同种型:
    Rat IgG2bkappa
  • 推荐稀释度:
  • 免疫原:
    Recombinant mouse TLR3 protein (aa 180-385).
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    ABM24E5
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    0.5mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
  • 产品特点:
  • 纯度:
    Protein G purified.
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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