anti-TLR4 (human), mAb (ABM19C4) (R-PE) - 深圳欣博盛生物科技有限公司

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anti-TLR4 (human), mAb (ABM19C4) (R-PE)

品牌： Adipogen

产品货号： AG-20T-0303R-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-TLR4 (human), mAb (ABM19C4) (R-PE)
别名:

Toll-like Receptor 4; TOLL; hToll; CD284; ARMD10
产品描述:

TLR4 (Toll-like Receptor 4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It was the first TLR identified TLR in mammals and most studied member of the TLR family. TLR4 recognizes the active lipid A component of lipopolysaccharide (LPS) from Gram-negative bacteria in conjunction with LY96 (also referred to MD-2), CD14 and LPS-binding protein (LBP) and consequently mediates the innate immune response to bacterial lipopolysaccharide (LPS). Additionally, it is also involved in LPS-independent responses triggered by endogenous DMAPs, such as heat shock proteins (HSPs) or HMGB1. TLR4 signals via MYD88, TIRAP and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response in various cell types. In complex with TLR6, it was shown to promote sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. The potency with which this TLR activates inflammatory pathways makes it an ideal target for therapeutic intervention and adjuvant development. A broad range of clinical studies have examined the adjuvant activity of TLR4 activators in vaccines against infectious and tumor antigens.
反应种属:
宿主来源:
实验应用:

FACS
靶标/特异性:
同种型:

Mouse IgG2bkappa
推荐稀释度:
免疫原:

Recombinant human TLR4 protein (aa 45-320).
免疫原种属:
克隆性:
克隆号:

ABM19C4
纯化方式:
偶联:

R-PE
产品浓度:

0.2mg/ml
表达系统:
阳性对照:
保存温度:

+4°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS containing 0.05% sodium azide.
有效期:

Stable for at least 6 months after receipt when stored at +4°C.
产地:

瑞士
外观:
生产商:
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URL:
灵敏度:
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检测方法:
样本类型:

Liquid. In PBS containing 0.05% sodium azide.
产品特点:
纯度:

Protein G purified.
生物活性:
内毒素水平:
来源:
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