anti-TLR5 (human), mAb (ABM22G1) (FITC) - 深圳欣博盛生物科技有限公司

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anti-TLR5 (human), mAb (ABM22G1) (FITC)

品牌： Adipogen

产品货号： AG-20T-0304F-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-TLR5 (human), mAb (ABM22G1) (FITC)
别名:

Toll-like Receptor 5; Toll/interleukin-1 Receptor-like Protein 3; TIL3; MELIOS; SLE1; SLEB1
产品描述:

TLR5 (Toll-like Receptor 5) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor, via a conserved region within flagellin, the D1 portion/domain. Binding of flagellin induces the dimerization of TLR5, which in turn recruits MyD88. The recruitment of MyD88 leads to subsequent activation of IRAK4, IRAK1, TRAF6 and eventually IkappaB kinases. Activation of IkappaB kinases mobilizes the nuclear factor NF-kappaB and stimulates many downstream gene expressions, which initiate the canonical proinflammatory pathway, including TNF-alpha production. TLR5 may play a role in inflammatory bowel disease (IBD). Lower levels of TLR5 expression have been found in patients exhibiting moderate to severe ulcerative colitis (UC). TLR5 is suggested to be possibly involved in HPV induced inflammation and subsequent cervical neoplasia formation. It has been reported that TLR5 expression is detected in both ovarian epithelium and ovarian cancer cell lines, suggesting a possible role of TLR5 in inflammation induced ovarian cancer onset. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus and susceptibility to legionnaire disease, highlighting the importance of TLR5 in microbial recognition particularly at the mucosal surface.
反应种属:
宿主来源:
实验应用:

FACS
靶标/特异性:
同种型:

Mouse IgG2akappa
推荐稀释度:
免疫原:

Recombinant human TLR5 protein (aa 261-420).
免疫原种属:
克隆性:
克隆号:

ABM22G1
纯化方式:
偶联:

FITC
产品浓度:

0.2mg/ml
表达系统:
阳性对照:
保存温度:

+4°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
有效期:

Stable for at least 6 months after receipt when stored at +4°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
产品特点:
纯度:

Protein G purified.
生物活性:
内毒素水平:
来源:
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PubChem CID: