anti-TLR7 (human), mAb (ABM2C27) (FITC) - 深圳欣博盛生物科技有限公司

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anti-TLR7 (human), mAb (ABM2C27) (FITC)

品牌： Adipogen

产品货号： AG-20T-0306F-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-TLR7 (human), mAb (ABM2C27) (FITC)
别名:

Toll-like Receptor 7
产品描述:

TLR7 (Toll-like Receptor 7) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is a nucleotide-sensing TLR. TLR7 and TLR8 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their natural ligands, and they are also activated by synthetic small-molecular-weight compounds of the imidazoquinoline family. Both TLR7 and TLR8 signal via MYD88 and TRAF6, leading to NF-kappaB and antiviral factor, such as IRF family activation, cytokine secretion and the inflammatory response. They are localized intracellularly to endosomal membranes and act as potent activators of innate immune responses upon viral infection. The TLR7 gene is predominantly expressed in lung, placenta and spleen, and lies in close proximity to TLR8 on chromosome X. TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus (SLE) as well as in the regulation of antiviral immunity. Recently, small molecule TLR7/8 agonists have demonstrated potential as vaccine adjuvants, since they directly activate APCs and can enhance both humoral and cellular immune responses, especially Th1 responses. This makes the TLR7/8 signaling pathways interesting therapeutic targets.
反应种属:
宿主来源:
实验应用:

FACS
靶标/特异性:
同种型:

Mouse IgG1kappa
推荐稀释度:
免疫原:

Recombinant human TLR7 protein (aa 500-900).
免疫原种属:
克隆性:
克隆号:

ABM2C27
纯化方式:
偶联:

FITC
产品浓度:

0.2mg/ml
表达系统:
阳性对照:
保存温度:

+4°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
有效期:

Stable for at least 6 months after receipt when stored at +4°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
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检测方法:
样本类型:

Liquid. In 10mM TRIS containing 150mM NaCl and 0.05% sodium azide.
产品特点:
纯度:

Protein G purified.
生物活性:
内毒素水平:
来源:
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PubChem CID: