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产品名称:
anti-HES1, mAb (7H11)
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别名:
hHL; HES1; BHLHB39; bHLHb39; Hairy Homolog; Hairy-like Protein; Transcription Factor HES-1; Hairy and Enhancer of Split 1; Class B Basic Helix-Loop-Helix Protein 39
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产品描述:
The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.
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反应种属:
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宿主来源:
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实验应用:
ELISA, FACS, IP, WB
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靶标/特异性:
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同种型:
Mouse IgG2bkappa
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推荐稀释度:
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免疫原:
Recombinant human Hes1 protein fused to a His-tag.
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免疫原种属:
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克隆性:
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克隆号:
7H11
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纯化方式:
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偶联:
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产品浓度:
1mg/ml
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
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产品形式:
liquid
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存储溶液:
Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
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有效期:
Stable for at least 1 year after receipt when stored at -20°C.
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产地:
瑞士
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外观:
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URL:
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灵敏度:
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检测方法:
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样本类型:
Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
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内毒素水平:
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PubChem CID: