anti-IL-33 (mouse), mAb (rec.) (blocking) (Bondy-1-1) (preservative free)

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品牌： Adipogen

产品货号： AG-27B-0013PF-C100

规格： 100 ug

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折后价：

数量： - +

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产品名称:

anti-IL-33 (mouse), mAb (rec.) (blocking) (Bondy-1-1) (preservative free)
别名:

Interleukin-33; IL-1F11; NF-HEV
产品描述:

Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. Anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
反应种属:
宿主来源:

Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
实验应用:

ELISA, FUNC (Blocking)
靶标/特异性:
同种型:

Mouse IgG2b
推荐稀释度:
免疫原:

Mouse recombinant IL-33.
免疫原种属:
克隆性:
克隆号:

Bondy-1-1
纯化方式:
偶联:
产品浓度:

Please Inquire.
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. In PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: