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Serum Amyloid A antibody [585]
品牌: GeneTex
产品货号: GTX18792
规格: 250μg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Serum Amyloid A antibody [585]
  • 别名:
    Serum Amyloid A1 , Pig4 , Saa , Saa2 , Tp53I4 , Saa1
  • 产品描述:
  • 反应种属:
    Human
  • 宿主来源:
    Mouse
  • 实验应用:
    ELISA, WB
  • 靶标/特异性:
  • 同种型:
    IgG2b
  • 推荐稀释度:
  • 免疫原:
    Highly purified recombinant human SAA (MW: 12 kDa)
  • 免疫原种属:
  • 克隆性:
    Monoclonal
  • 克隆号:
    585
  • 纯化方式:
    Protein G purified
  • 偶联:
    Unconjugated
  • 产品浓度:
    1 mg/ml (Please refer to the vial label for the specific concentration.)
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
  • 运输温度:
    4°C
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    Liquid
  • 存储溶液:
    PBS pH7.2
  • 有效期:
  • 产地:
    美国
  • 外观:
  • 生产商:
  • 功能与背景:
    The serum amyloid A family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumour tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparin sulphate. Also adhesion motifs were identified and new functions affecting cell adhesion, migration, proliferation, and aggregation were discovered. These findings emphasize the importance of SAA in various physiological and pathological processes including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair, it is thus thought to be an integral part of the disease process.
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    PBS pH7.2
  • 产品特点:
  • 纯度:
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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