anti-CD112R (mouse), pAb (IN109) - 深圳欣博盛生物科技有限公司

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anti-CD112R (mouse), pAb (IN109)

品牌： Adipogen

产品货号： AG-25B-0035-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-CD112R (mouse), pAb (IN109)
别名:

CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG
产品描述:

CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.
反应种属:
宿主来源:

Rabbit
实验应用:

ELISA, WB
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同种型:
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免疫原:

Recombinant mouse CD112R.
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产品浓度:

1mg/ml
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保存温度:

-20°C
运输温度:

BLUE ICE
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产品形式:

liquid
存储溶液:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
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Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
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