anti-Gasdermin D (mouse), pAb (IN110) - 深圳欣博盛生物科技有限公司

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anti-Gasdermin D (mouse), pAb (IN110)

品牌： Adipogen

产品货号： AG-25B-0036-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-Gasdermin D (mouse), pAb (IN110)
别名:

Gasdermin Domain-containing Protein 1; Gasdermin-D (C-terminal); GSDMD-CT; Gsdmd
产品描述:

Inflammasomes are multimeric protein complexes that comprise a sensor (e.g. NLRP3), an adaptor (ASC/Pycard) and the procaspase-1. An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1, which further induces maturation of interleukin-1beta and -18 (IL-1beta and IL-18) through proteolytic cleavage of pro-IL-1beta and pro-IL-18. Activated caspase-1, and also the recently characterized caspase-11 non-canonical inflammasome pathway, also cleave the intracellular gasdermin D, which leads to a particular form of inflammatory cell death called pyroptosis. The gasdermin family members contain N-terminal domains that are capable of forming membrane pores to induce cytolysis, whereas the C-terminal domains of gasdermins function as inhibitors of such cytolysis through intramolecular domain association. Caspase-1 or -11 cleavage of gasdermin D is required for regulation of pyroptosis: upon protease cleavage of the gasdermin N- and C-domain linker, the disruption of the intramolecular domain interaction in the presence of lipids releases the N-domain to assemble oligomeric membrane pores that trigger cell death. Gasdermin D seems to be a key effector in the LPS-induced lethal sepsis.
反应种属:
宿主来源:

Guinea pig
实验应用:

ELISA, WB
靶标/特异性:
同种型:
推荐稀释度:
免疫原:

Recombinant mouse gasdermin D (C-terminus).
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产品浓度:

1mg/ml
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保存温度:

-20°C
运输温度:

BLUE ICE
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产品形式:

liquid
存储溶液:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
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样本类型:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
产品特点:
纯度:

>95% (SDS-PAGE)
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