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Presenilin 2 antibody
品牌: GeneTex
产品货号: GTX18041
规格: 250μg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Presenilin 2 antibody
  • 别名:
    presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2
  • 产品描述:
  • 反应种属:
    Human, Mouse, Rat
  • 宿主来源:
    Chicken
  • 实验应用:
    ELISA, IHC, WB
  • 靶标/特异性:
  • 同种型:
    IgY
  • 推荐稀释度:
  • 免疫原:
    Two synthetic peptides (Human).
  • 免疫原种属:
  • 克隆性:
    Polyclonal
  • 克隆号:
  • 纯化方式:
    IgY fraction
  • 偶联:
    Unconjugated
  • 产品浓度:
    1 mg/ml (Please refer to the vial label for the specific concentration.)
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
  • 运输温度:
    4°C
  • 细胞定位:
  • 预期分子量:
    50
  • 产品形式:
    Liquid
  • 存储溶液:
  • 有效期:
  • 产地:
    美国
  • 外观:
  • 生产商:
  • 功能与背景:
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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  • 分子式:
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