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IL-37 (human) ELISA Kit (Twin Plex)
品牌： Adipogen
产品货号： AG-45A-0041YTP-KI01
规格： 2 x 96 wells

报价：
折后价：

数量： - +
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  • 产品名称:
    IL-37 (human) ELISA Kit (Twin Plex)
  • 别名:
    Interleukin-1 Family Member 7; IL-1F7; FIL1 zeta; IL-1X; Interleukin-1 Homolog 4; IL-1H4; Interleukin-1 zeta; IL-1 zeta; IL-1RP1; IL1F7; FIL1Z, IL1H4, IL1RP1
  • 产品描述:
    IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption. A recent study indicates that IL-37 protein forms a head-to-head homodimer and this structure limits its bioactivity. Variants with mutations converting the cytokine into a monomeric form are 13 fold more active than the dimeric IL-37.
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    +4°C
  • 运输温度:
    BLUE ICE
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  • 有效期:
    12 months after the day of manufacturing. See expiry date on ELISA Kit box.
  • 产地:
    瑞士
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