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产品名称:
IL-1alpha (human) (rec.)
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别名:
Interleukin-1alpha; IL-1F1; IL-1A
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产品描述:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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反应种属:
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宿主来源:
HEK 293 cells
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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偶联:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~19kDa (SDS-PAGE)
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产品形式:
solid
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存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
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有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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产地:
瑞士
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样本类型:
Lyophilized from 0.2µm-filtered solution in PBS.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.001 ng/ml, corresponding to a specific activity of > 1 x 109units/mg.
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内毒素水平:
<0.01EU/µg protein (LAL test; Lonza).
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