CD40 (human):Fc (human) (rec.) - 深圳欣博盛生物科技有限公司

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CD40 (human):Fc (human) (rec.)

品牌： Adipogen

产品货号： CHI-HF-210CD40-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

CD40 (human):Fc (human) (rec.)
别名:

Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5; CD40L Receptor
产品描述:

CD40 [TNFRSF5] is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by the inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response and a lack of germinal center formation.
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宿主来源:

CHO cells
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保存温度:

-20°C
运输温度:

BLUE ICE
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产品形式:

solid
存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.
有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized from 0.2µm-filtered solution in PBS.
产品特点:
纯度:

>98% (SDS-PAGE)
生物活性:

Measured by its binding ability in a functional ELISA assay.
内毒素水平:

<0.06EU/µg protein (LAL test; Lonza).
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