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NUCB2 (mouse) (rec.) (His)
品牌： Adipogen
产品货号： AG-40A-0074-C010
规格： 10 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    NUCB2 (mouse) (rec.) (His)
  • 别名:
    DNA-binding Protein NEFA; Prepronesfatin; Nucb2; Nesfatin
  • 产品描述:
    Nucleobindin-2 (NUCB2; Prepronesfatin) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucleobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. NUCB2 can be cleaved into three polypeptides: nesfatin-1, nesfatin-2, and nesfatin-3. Anorexigenic effects have been described for nesfatin-1 that plays an important role in hypothalamic pathways regulating food intake and energy homeostasis and acting in a leptin-independent manner. Nesfatin-1 may also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. Nucleobindin-2 is therefore reported to reduce food intake after administration, mostly refering to the cleaved peptide nesfatin-1. Excess nucleobindin-2/nesfatin-1 in the brain leads to a loss of appetite, lack of the protein in the brain leads to an increase of appetite.
  • 反应种属:
  • 宿主来源:
    E. coli
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  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~55kDa (SDS-PAGE)
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
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  • 检测方法:
  • 样本类型:
    Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
  • 产品特点:
  • 纯度:
    >90% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <1EU/µg purified protein (LAL test; Lonza).
  • 来源:
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