izTRAIL, Soluble (human) (rec.) MultiPack - 深圳欣博盛生物科技有限公司

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izTRAIL, Soluble (human) (rec.) MultiPack

品牌： Adipogen

产品货号： AG-40B-0069-5010

规格： 5 x 10 ug

报价：

折后价：

数量： - +

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产品名称:

izTRAIL, Soluble (human) (rec.) MultiPack
别名:

Apo-2L; TNFSF10; CD253
产品描述:

izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper (iz) motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL (shTRAIL). Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL. These properties render izTRAIL highly suitable for both, in vitro and in vivo use, particularly for studies in which investigators plan to transfer their in vitro results into an in vivo system with human cancer cells in xenotransplant settings examining susceptibility to TRAIL-induced apoptosis.
反应种属:
宿主来源:

E. coli
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免疫原:
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产品浓度:

0.1mg/ml after reconstitution
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~82kDa as stable trimers (determined by size exclusion chromatography) ~28kDa as monomer (determined by SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20.
有效期:

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:

Induces apoptosis in vitro in different human cancer cell lines with an EC50 of 5-200ng/ml, depending on the individual cell line used. Recombinant izTRAIL does not kill 4-day cultures of primary human hepatocytes (PHH) at concentrations of at least up to 1µg/ml (Ganten 2006). Good bioavailability in vivo, shows no toxic effects in mice at doses of at least up to 500µg per day (Wissink 2006).
内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).
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