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TIP60 (human) (rec.) (His) (highly active)
品牌： Adipogen
产品货号： AG-40T-0019-C002
规格： 2 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    TIP60 (human) (rec.) (His) (highly active)
  • 别名:
    Histone Acetyltransferase HTATIP; Histone Acetyltransferase KAT5; Lysine Acetyltransferase 5; 60 kDa Tat-interactive Protein
  • 产品描述:
    TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
  • 反应种属:
  • 宿主来源:
    Sf21 cells
  • 实验应用:
  • 靶标/特异性:
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  • 推荐稀释度:
  • 免疫原:
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  • 纯化方式:
  • 偶联:
  • 产品浓度:
    Lot dependent (0.2-0.5mg/ml)
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    DRY ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -80°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
    100-200ng are required for standard HAT assay.
  • 内毒素水平:
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  • 表达方式:
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