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产品名称:
HGF (human) (rec.)
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别名:
Hepatocyte Growth Factor; Hepatopoietin-A; Scatter Factor
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产品描述:
Human hepatocyte growth factor (HGF) is synthesized as a biologically inactive single chain precursor, which is cleaved by a specific, extracellular serum serine protease to a fully active heterodimer. It stimulates the motility and invasion of several cancer cell types and can induce angiogenesis. All biological responses induced by HGF are elicited by binding to its transmembrane tyrosine kinase receptor. HGF function is essential for normal development. Knockout studies have demonstrated that both ligand and receptor deficient mice display an embryonic lethal phenotype. HGF synergizes with basic FGF in the induction of angiogenesis. HGF is a potent mitogen for mature parenchymal hepatocyte cells and is a pleiotrophic cytokine. It acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. It is an activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization.
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反应种属:
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宿主来源:
Sf9 cells
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实验应用:
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同种型:
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偶联:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~78kDa
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产品形式:
solid
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存储溶液:
Lyophilized.
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有效期:
Stable for at least 6 months after receipt when stored at -20°C.
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产地:
瑞士
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样本类型:
Lyophilized.
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产品特点:
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纯度:
>95% (SDS-PAGE)
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生物活性:
The activity was assayed for scattering activity in the MDCK cell assay. The ED50 for this effect is typically at 1.0-5.0ng/ml.
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