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Irisin (human, recombinant)
品牌: Cayman
产品货号: 11451
规格: 100 µg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Irisin (human, recombinant)
  • 别名:
    Fibronectin Type III Domain 5|FNDC5|FRCP2|PeP
  • 产品描述:
    Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.{21133} Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.{20433} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.
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  • 阳性对照:
  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris pH 8.0, 150 mM sodium chloride, and 20% glycerol
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥85% estimated by SDS-PAGE
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  • CAS号:
    9037-90-5
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