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Nicotinamide N-Methyltransferase (human, recombinant)
品牌: Cayman
产品货号: 15138
规格: 100 µg

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数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Nicotinamide N-Methyltransferase (human, recombinant)
  • 别名:
    NNMT
  • 产品描述:
    Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.{24617} NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.{24616,24618,24614} The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.{24614,24772} Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.{24614}
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris, pH 8.0, containing 500 mM sodium chloride, 5% glycerol, and 1 mM DTT
  • 存储溶液:
  • 有效期:
    180
  • 产地:
    美国
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  • 纯度:
    ≥95% estimated by SDS-PAGE
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