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JAK2 (human, recombinant)
品牌: Cayman
产品货号: 33742
规格: 20 µg

报价:
折后价:

数量: - +
产品详情
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  • 产品名称:
    JAK2 (human, recombinant)
  • 别名:
    Janus-Associated Kinase 2|JTK10|Tyrosine-protein Kinase JAK2
  • 产品描述:
    JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling.{19346,54923} It is composed of N-terminal FERM and SH2 domains, a regulatory pseudokinase domain, and a C-terminal kinase domain.{19346} It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.{54921,54922} Activation of these cytokine receptors activates JAK2 and induces its dimerization and kinase activity, leading to JAK2 phosphorylation of STAT transcription factors and transcription of immune-related target genes. JAK2 signaling is inhibited by the suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3.{54924,54925} Gain-of-function mutations in JAK2 are associated with various blood disorders, including leukemias and myeloproliferative neoplasms.{54922} Cayman’s JAK2 (human, recombinant) protein can be used for enzyme activity assays.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    Lyophilized from sterile 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 3 mM DTT, 0.04% Tween 20, and 20% glycerol
  • 存储溶液:
  • 有效期:
    180
  • 产地:
    美国
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  • 纯度:
    ≥71% estimated by SDS-PAGE
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