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Thioredoxin Reductase 2 (human, recombinant)
品牌: Cayman
产品货号: 39625
规格: 250 µg

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数量: - +
产品详情
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  • 产品名称:
    Thioredoxin Reductase 2 (human, recombinant)
  • 别名:
    NADPH-dependent Thioredoxin Reductase 2|TrxR2|Txnrd2
  • 产品描述:
    Thioredoxin reductase 2 (TrxR2) is an oxidoreductase encoded by the TXNRD2 gene in humans and a member of the antioxidant thioredoxin system.{14257} It exists as a homodimer and contains a dimer interface domain, FAD- and NADPH-binding domains, an N-terminal redox catalytic site, and a C-terminal selenocysteine residue, which is essential for the catalytic activity of TrxR2.{14257,65805} TrxR2 is ubiquitously expressed and localizes primarily to the mitochondria.{52832} It catalyzes the NADPH-dependent reduction of oxidized thioredoxin 2 (Trx2), restoring the disulfide reductase function of Trx2, which reduces peroxiredoxin-3 (Prx3) dimers.{52833,57136} TrxR2 has roles in the maintenance of mitochondrial integrity and redox homeostasis in the aging heart and in the regulation of chondrocyte viability, proliferation, and differentiation.{65805} Genome-wide deletion of Txnrd2 is embryonic lethal in mice.{65806} TXNRD2 expression and TrxR2 protein levels are increased in bone biopsies from patients with osteosarcoma that later progress to metastatic disease.{65807} SNPs in TXNRD2 are associated with serum markers of selenium status in patients with advanced- or high-stage, but not localized low-grade, prostate cancer.{65808} Cayman’s Thioredoxin Reductase 2 (human, recombinant) protein can be used for enzyme activity assays.
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  • 保存温度:
    -20
  • 运输温度:
    -20
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  • 产品形式:
    TE buffer with 50% glycerol
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥95% estimated by SDS-PAGE
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