产品描述:
Gossypetin is a flavonoid that has been found in H. sabdariffa and has diverse biological activities.{60456,60457,60458} It inhibits the MAP2K kinases MKK3 and MKK6 in a concentration-dependent manner, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells when used at a concentration of 20 µM.{60456} Gossypetin scavenges DPPH (Item No. 14805) radicals and inhibits copper-induced lipid peroxidation in cell-free assays.{60457} It reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis when administered at a dose of 10 mg/kg.{60458}