产品描述:
Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha'=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.