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产品名称:
PF-2545920
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别名:
2-(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)-phenoxymethyl)quinoline; MP-10
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产品描述:
Potent and selective phosphodiesterase 10A (PDE10A) inhibitor (IC50=1.26nM) in vitro and in vivo. PDE10A is a cGMP and cAMP degrading PDE isozyme with neurological importance and was shown to be implicated in the regulation of energy homeostasis. Inhibition of PDE10A leads to interference of the breakdown of the secondary messenger cAMP and cGMP. Anti-psychotic agent. Useful for the treatment of schizophrenia. Anticancer agent. Inhibits colon tumor cell growth for which high levels of PDE10A have been reported. Antiobesity and antidiabetic agent. Induces browning in white adipose tissue (WAT).
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
392.5
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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产地:
瑞士
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纯度:
>98% (HPLC)
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Accession #:
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CAS号:
898562-94-2
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分子式:
C25H20N4O
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溶解度:
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PubChem CID: