产品描述:
KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist.{68471} It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea and colonic inflammatory cell infiltration, and increases colon length in an IL10-/- mouse model of colitis. KRP 203 inhibits inflammatory cell infiltration and prolongs allograft survival in a rat model of minor histocompatibility complex-disparate heart transplantation.{16428}