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产品名称:
Dienogest
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别名:
STS 557; BAY 86-5258; (17alpha)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile, 17-cyanomethyl-17-hydroxy-estra-4,9-dien-3-one; Dienogestril; Endometrion
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产品描述:
Dienogest is an agonist of the progesterone receptor (PR). It is an orally active synthetic progestogen with approximately 10% of the relative affinity of progesterone. However it shows very potent progestagenic effects in the endometrium with some antiandrogenic activity and without any androgenic, glucocorticoid or mineralocorticoid effects. It has been used alone or in combination as a contraceptive and to treat uterine fibroids. Dienogest inhibits ovulation primarily through peripheral action rather than by central action on gonadotrophin secretion. Unlike other progestogens, except in the case of its strong effects in the uterus, dienogest is said to lack antiestrogenic effects, and does not antagonize the beneficial effects of estradiol, for instance in the metabolic and vascular systems. Dienogest also showed some possible antiprogestogenic activity in one animal bioassay when administered before but not at the same time as progesterone. It has shown to have anti-inflammatory activity.
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反应种属:
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宿主来源:
Synthetic
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实验应用:
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同种型:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
+4°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
311.42
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at +4°C.
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产地:
瑞士
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纯度:
>98% (HPLC)
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Accession #:
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CAS号:
65928-58-7
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分子式:
C20H25NO2
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溶解度:
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PubChem CID: