产品描述:
Potent and selective endothelin receptor A (ETA) antagonist [1-3]. Suppresses the ET-1-induced decrease of LPL activity [4]. Shows protective effects in ischemic acute renal failure [5]. Neuroprotective [6, 10]. Anti-hypertensive [7]. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation [8]. Cardiovascular agent [9]. Reduces myocardial infarct size and oxidant injury [11]. Selected Reviews [12, 13].