产品描述:
Mogroside IIIE is a cucurbitane glycoside that has been found in S. grosvenorii and has anti-inflammatory activity.{66617,66618} It inhibits LPS-induced secretion of IL-1β, IL-6, and Tnf-α from, as well as LPS-induced increases in toll-like receptor 4 (TLR4) levels in, RAW 264.7 macrophages when used at a concentration of 50 µM.{66617} Mogroside IIIE (20 mg/kg) increases in bronchoalveolar lavage fluid (BALF) levels of IL-1β, IL-6, and TNF-α, and increases in lung tissue myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury. It decreases lung fibrosis, as well as increases animal survival and reduces lung levels of matrix metalloproteinase-9 (MMP-9), in a mouse model of pulmonary fibrosis induced by the glycopeptide bleomycin (Item No. 13877) when administered at a dose of 20 mg/kg per day.{66618} Formulations containing mogroside IIIE have been used as sweeteners in food products.