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PAMAM Dendrimer G4.0 Amine (water solution)
品牌: Cayman
产品货号: 39074-500 mg
规格: 500 mg

报价:
折后价:

数量: - +
产品详情
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  • 产品名称:
    PAMAM Dendrimer G4.0 Amine (water solution)
  • 别名:
    PAMAM G4.0|Polyamidoamine Dendrimer G4.0
  • 产品描述:
    PAMAM dendrimer G4.0 amine (PAMAM G4.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.{51536,72161} It is approximately 45 Å in diameter and has 64 surface groups.{51536} It inhibits fibril formation by α-synuclein in a cell-free assay when used at concentrations of 1 and 2 µM.{72162} PAMAM G4.0 is active against E. coli (IC50 = 3.8 µg/ml) and toxic to zebrafish embryos, inducing mortality at 120 hours post-fertilization when used at concentrations ranging from 0.5 to 20 µM.{51536,51537} PAMAM G4.0 (100 and 300 mg/kg) in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice without inducing gastrointestinal toxicity.{51539} PEG-modified PAMAM G4.0 in complex with folic acid (Item No. 20515), 5-fluorouracil (5-FU; Item No. 14416), and the imaging agent technetium-99m (PEG-PAMAM G4-FA-5FU-99mTc) localizes to the tumor, as well as the liver and spleen, in a 4T1 murine mammary tumor model.{72161}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    14214.2
  • 产品形式:
    A solution in water
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • CAS号:
    163442-67-9
  • 分子式:
    [NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
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