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PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)
品牌： Cayman
产品货号： 39108-1 g
规格： 1 g

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数量： - +
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  • 产品名称:
    PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)
  • 别名:
    PAMAM G3.5 Carboxylate|Polyamidoamine Dendrimer G3.5 Carboxylate
  • 产品描述:
    PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro and in vivo.{67553,51539} It is approximately 66.1 Å in diameter in water and has 48 surface groups.{67554} PAMAM G3.5 is active against E. coli (IC50 = 22 mg/ml) and increases the mitochondrial membrane potential of isolated rat liver mitochondria when used at concentrations ranging from 10 to 50 µM.{51537,51538} Unlike amine-terminated PAMAM G4.0, PAMAM G3.5 (20 µM) is not toxic to zebrafish embryos.{51536} A fluorescently labeled form of PAMAM G3.5 enters Caco-2 cells via dynamin-, clathrin-, and caveolin-mediated endocytosis.{51535} Conjugates of PAMAM G3.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.08, 4.1, 0.39, and 3 µM, respectively).{67553} PAMAM G3.5 in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice.{51539}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    12927.7
  • 产品形式:
    A solution in water
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • CAS号:
    192948-77-9
  • 分子式:
    [NH2(CH2)2NH2]:(G=3.5);dendri PAMAM(NHCH2CH2COONa)64
  • 溶解度:
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