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PAMAM Dendrimer G4.5 Carboxylate (sodium salt) (water solution)
品牌： Cayman
产品货号： 39109-1 g
规格： 1 g

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数量： - +
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  • 产品名称:
    PAMAM Dendrimer G4.5 Carboxylate (sodium salt) (water solution)
  • 别名:
    PAMAM G4.5 Carboxylate|Polyamidoamine Dendrimer G4.5 Carboxylate
  • 产品描述:
    PAMAM dendrimer G4.5 carboxylate (PAMAM G4.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system.{67597} It is approximately 87.9 Å in diameter in water and has 96 surface groups.{67554} Unlike the amine-terminated PAMAM G5.0 (Item No. 39075), it does not rupture bilayer lipid membranes when used at a concentration of 50 µM.{67598} PAMAM G4.5 carboxylate disulfur-linked aggregates (10 µg/ml) encapsulating the phenol ferulic acid (Item No. 19871) and the mitotic inhibitor paclitaxel (Item No. 10461) induce apoptosis and decrease the mitochondrial membrane potential in multidrug-resistant KB-8-5 epidermal carcinoma cells.{67597} Complexes of PAMAM G4.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 620 nM).{67596} A fluorescently labeled form of PAMAM G4.5 carboxylate selectively accumulates in tumors and kidneys over liver, spleen, heart, and lungs in a 4T1 murine mammary carcinoma model.{67599}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    26251.9
  • 产品形式:
    A solution in water
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • CAS号:
    202009-66-3
  • 分子式:
    [NH2(CH2)2NH2]:(G=4.5);dendri PAMAM(NHCH2CH2COONa)128
  • 溶解度:
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