产品描述:
5-O-Methylvisammioside is a chromone that has been found in S. diviaricata and has diverse biological activities.{72208,72209,72210,72211} It inhibits the protein-protein interaction between histone H3 and 14-3-3ε and phosphorylation of histone H3, as well as induces cell cycle arrest at the G2/M phase, in HT-29 colon cancer cells when used at a concentration of 10 µM.{72208} 5-O-Methylvisammioside (10-100 µM) inhibits histamine release induced by the mast cell degranulator compound 48/80 (Item No. 22173) in LAD 2 mast cells.{72209} It reduces LPS-induced increases in nitric oxide (NO), malondialdehyde (MDA), and nuclear NF-κB levels in BV-2 microglia and decreases immobility time in the tail suspension and forced swim tests in mice.{72210} 5-O-Methylvisammioside (400 µg/kg) inhibits perivascular adventitia leukocyte infiltration and improves neurological deficits in a rat model of subarachnoid hemorrhage-induced vasospasm.{72211} It has been used as a quality control marker of S. diviaricata roots.{72212}