深圳欣博盛生物科技有限公司

SAP102 Antibody / Synapse-associated protein 102

SAP102 antibody targets synapse-associated protein 102, encoded by the DLG3 gene. Synapse-associated protein 102 is a member of the membrane-associated guanylate kinase (MAGUK) family of scaffold proteins, which organize signaling complexes at neuronal synapses. SAP102 contains multiple protein interaction domains, including PDZ, SH3, and guanylate kinase-like domains, enabling it to anchor receptors, ion channels, and signaling molecules within the postsynaptic density.

Functionally, synapse-associated protein 102 plays an important role in synaptic development and plasticity by regulating the trafficking and stabilization of glutamate receptors, particularly NMDA receptor subunits. SAP102 is especially prominent during early brain development, where it contributes to synapse formation and maturation. By coordinating multiprotein assemblies at excitatory synapses, SAP102 influences synaptic strength and signal transduction. A SAP102 antibody supports studies focused on synaptic organization, receptor trafficking, and neuronal signaling pathways.

DLG3 expression is enriched in the central nervous system, with strong expression in cortical and hippocampal neurons. Subcellular localization is primarily postsynaptic, where SAP102 associates with the postsynaptic density, although distribution can vary depending on neuronal activity and developmental stage. Compared with other MAGUK family members, SAP102 shows a more dynamic association with synaptic membranes, consistent with its role in synapse remodeling during development.

From a disease relevance perspective, altered SAP102 expression or function has been linked to neurodevelopmental and cognitive disorders, where disrupted synaptic scaffolding can impair neuronal communication. At the molecular level, synapse-associated protein 102 functions as a non-enzymatic adaptor that integrates structural and signaling components rather than directly catalyzing reactions. SAP102 antibody reagents support research applications examining synaptic architecture, neurodevelopment, and postsynaptic signaling networks, with NSJ Bioreagents providing reagents intended for research use.

Human, Mouse, Rat

Rabbit

WB, IHC-P

Rabbit IgG

A recombinant human protein corresponding to amino acids E749-L817 was used as the immunogen for the SAP102 antibody.

Polyclonal (rabbit origin)

Antigen affinity

After reconstitution, the SAP102 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

美国