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折扣/货期| 货号：33-561 | 规格：100 ug | 目录价：￥10986.3 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Thymidylate Synthase Antibody [TS106]
别名:
TYMS, HsT422, MGC88736, TMS, TS, TSase, HST422
反应种属:
Human
宿主来源:
Mouse
实验应用:
WB,Flow,IF,IHC
同种型:
IgG1, kappa
克隆性:
Monoclonal
克隆号:
TS106
纯化方式:
Protein G affinity chromatography
偶联:
Unconjugated
产品浓度:
0.2 mg/mL
保存温度:
Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
产地:
美国
生产商:
Prosci
功能与背景:
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
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